Seattle Seahawks vs Arizona Cardinals Prediction and Picks - September 25, 2025
Use Code WWWC Thursday Night Football, and we have a Seattle Seahawks vs Arizona Cardinals Prediction locked and loaded for you. Seattle enters this game off a 44-13 home win over the Saints. Arizona comes in off a hard-fought 16-15 loss to the 49ers on the road. The Seahawks won both meetings last year and have now won seven in a row in this series. Can Arizona finally break through with a win? Read on to see our Seattle vs Arizona prediction.
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Seahawks Crush The Saints
The Seahawks are riding high after a dominant 44–13 win over the Saints, showcasing all three phases of the game in a performance that felt like a statement. Sam Darnold was efficient and decisive, throwing for 218 yards and two touchdowns while avoiding turnovers. Rookie wideout Tory Horton electrified the crowd with a 95-yard punt return touchdown and a blocked punt that set up another score. Seattle’s offense clicked early, scoring 38 points in the first half, and the defense smothered New Orleans, allowing just 13 points and forcing multiple three-and-outs. Head coach Mike Macdonald has this team playing fast, physical, and disciplined football, and they’ve quickly emerged as one of the most balanced squads in the NFC.
Offensively, Seattle has found a groove with Darnold at the helm and a deep cast of playmakers. Jaxon Smith-Njigba has stepped into a WR1 role, leading the team in receiving yards and consistently winning on intermediate routes. Kenneth Walker III remains a red-zone threat with three rushing touchdowns, and Cooper Kupp—though not yet dominant—commands attention from defenses. Horton’s emergence adds a vertical and special teams dimension that few teams can match. The offensive line has held up well despite injuries, and Klint Kubiak’s play-calling has leaned into tempo and spacing, allowing Darnold to make quick reads and avoid pressure.
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Defensively, the Seahawks have been stout, ranking second in scoring defense and top five in takeaways. Even with injuries to Devon Witherspoon and Julian Love, the secondary has held firm thanks to strong play from Derion Kendrick and Ty Okada. The front seven has been disruptive, limiting opponents to under 300 total yards in back-to-back games. Seattle’s ability to generate pressure without blitzing has allowed them to stay versatile in coverage, and their tackling has been sharp across the board. Against a Cardinals team missing its top running back, the Seahawks will look to force Kyler Murray into predictable passing situations and capitalize on third-and-long opportunities.
Cardinals Lose A Heartbreaker To The Niners
The Cardinals enter Thursday night licking their wounds after a gut-punch 16–15 loss to San Francisco, a game that ended on a walk-off field goal and saw star running back James Conner go down with a season-ending ankle injury. Arizona had taken a late lead thanks to a safety and a touchdown pass from Kyler Murray to Trey McBride, but couldn’t close out the final drive. The loss stung not just for the missed opportunity, but for the ripple effect of losing Conner, who had been the team’s most consistent offensive weapon. At 2–1, the Cardinals remain competitive, but the margin for error is shrinking fast.
Kyler Murray has been solid through three games, throwing for 542 yards and four touchdowns while adding 87 yards on the ground. His mobility remains a threat, but without Conner, Arizona’s offense risks becoming one-dimensional. Rookie Trey Benson will take over the lead back role, and while he’s flashed burst and vision, he lacks Conner’s power and pass protection reliability. Trey McBride leads the team in receiving yards and has become a go-to target in the red zone, while Marvin Harrison Jr. continues to develop as a deep threat. The offensive line has been average, and injuries to Will Hernandez and Garrett Williams could further strain protection against Seattle’s aggressive front.
Defensively, Arizona has been quietly effective, allowing just 17 points per game and ranking top five in red-zone defense. They’ve done well against weaker offenses, but Thursday presents a different challenge with Seattle’s speed and versatility. The Cardinals’ secondary is banged up, and their pass rush has struggled to generate consistent pressure, which could be problematic against Darnold’s quick-release passing game. Special teams have also been shaky, particularly in coverage—an area that Seattle exploited last week. For Arizona to stay competitive, they’ll need to control time of possession, win the turnover battle, and find creative ways to finish drives without Conner’s downhill presence.
Seattle Seahawks vs Arizona Cardinals Pick
Seattle vs Arizona Spread Pick
- Seattle +1.5 (4 Units)
Seattle +1.5 is a sharp play in Thursday night’s NFC West showdown, especially given how dominant the Seahawks have looked in their last two outings. They’ve outscored opponents 75–30 over that stretch, with Sam Darnold playing efficient, turnover-free football and the defense emerging as one of the league’s best. Seattle ranks second in points allowed (15.7 PPG) and fifth in yards per play defensively, showing discipline and speed at every level. Arizona, meanwhile, has benefited from a soft early schedule and just lost James Conner, their most reliable offensive weapon. With Kyler Murray averaging just 180.6 passing yards per game and facing a much tougher defensive front, the Cardinals could struggle to sustain drives.
Historically, Seattle has owned this matchup, winning seven straight against Arizona and covering the spread in six of those games. The Seahawks’ special teams have become a game-changing asset, and their offensive weapons—Jaxon Smith-Njigba, Kenneth Walker III, and Tory Horton—offer more explosiveness than Arizona’s current lineup. The Cardinals’ defense has posted strong situational stats, but those came against rookie and backup quarterbacks. Seattle represents a major step up in competition, and with momentum, matchup history, and a more complete roster, they’re well-positioned to not only cover the +1.5 but win outright.
Seattle vs Arizona Over/Under Pick
- Over 43.5 (5 Units)
The Over 43.5 is a strong play for Thursday night’s Seahawks–Cardinals matchup, with both teams combining to average 50 points per game, well above the posted total. Seattle’s offense has exploded for 75 points over its last two games, and Sam Darnold is operating with precision behind a versatile playbook. Arizona, while inconsistent, still has Kyler Murray’s mobility and red-zone creativity, and they’ve topped 20 points in two of three outings. With Seattle’s special teams capable of flipping field position and generating scores, and both defenses facing their toughest test yet, this game has all the ingredients for a shootout that clears the number.
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