Philadelphia 76ers vs Cleveland Cavaliers Picks and Prediction for Friday November 6, 2026

The Philadelphia 76ers will be on the road Friday night for a matchup against the Cleveland Cavaliers inside Rocket Mortgage FieldHouse in Cleveland, Ohio. The game is scheduled to begin at 7:30 PM ET, with coverage on Prime Video. Philadelphia comes into this game rolling 8-1 overall, riding a long winning streak following a 6-point road win. Cleveland is struggling this season, 4-4 overall, after losing 3 of the last 4, including 2 in a row after an 8-point road loss to Oklahoma City. Stay in the action with our NBA Picks.

Philadelphia looks to extend their streak

The Philadelphia 76ers offense has been consistent this season, averaging 111 points per game on 45% shooting from the floor. Defensively, Philadelphia is allowing 105.2 points per game this season, including an average of just 103.8 points across its last five victories. Tyrese Maxey leads the Philadelphia offense this season, averaging 28 points per game. Jaylen Brown is second on the roster, averaging 21.8 points, while Joel Embiid is adding 19.6 points and a team-high 10 rebounds per game. LeBron James is averaging 15.7 points and leads the team with 7.4 assists per game. VJ Edgecombe is contributing 12.5 points, while Anfernee Simons is averaging 10 points per game this season.

Offensively, Philadelphia was the better team in its last outing, scoring 112 points on 45% shooting from the floor and 38% from beyond the arc. Defensively, the 76ers did the work, allowing 106 points on 46% shooting. Philadelphia won the rebounding battle by eight and forced 12 turnovers in the victory. Jaylen Brown led the Philadelphia offense with 30 points on 19 shots.

Key Injury Report for Philadelphia:

• Adem Bona (GTD) - Back
• Dominick Barlow (Out) - Back
• Ariel Hukporti (OFS) - Achilles

Cleveland hunts another home win

The Cleveland Cavaliers offense is averaging 119.3 points per game on 46% shooting from the floor this season. Defensively, Cleveland has struggled, allowing 117.1 points per game this year, including an average of 118.3 points across its last three losses. Donovan Mitchell leads the Cleveland offense this season, averaging 22.5 points per game. Big man Evan Mobley is second on the roster, averaging 18.8 points and a team-high 8.2 rebounds per game. James Harden is averaging 16.6 points and leads the team with 6.2 assists per game. Jarrett Allen is contributing 13.3 points, while Meleek Thomas is averaging 13 points per game this season.

Defensively, Cleveland was severely outmatched in its last outing, allowing 124 points on 46% shooting from the floor and 42% from beyond the arc. Offensively, the Cavaliers scored the ball well, pouring in 116 points, including 72 in the second half, on 43% shooting from the floor and 39% from beyond the arc. Cleveland lost the rebounding battle and turned the ball over 14 times in the loss. Donovan Mitchell led the Cleveland offense with 27 points and six assists on 17 shots.

Key Injury Report for Cleveland:

• Tyrese Proctor (GTD) - Ankle
• Jaylon Tyson (Out) - Ankle
• Peyton Watson (GTD) _ Hamstring
• Jarrett Allen (GTD) - Knee

Philadelphia 76ers vs Cleveland Cavaliers Picks and Prediction

Pick: Cleveland Cavaliers -2.5

Cleveland has the advantage in this matchup with its ability to score from multiple areas of the floor and control the game defensively. The Cavaliers have enough size, athleticism, and offensive firepower to create problems for Philadelphia, especially around the basket. Philadelphia has shown the ability to score at a high level this season, but Cleveland has the depth and versatility necessary to match that production throughout the game. The Cavaliers should also benefit from playing on their home floor, where their defensive pressure and ability to control the glass could become deciding factors. Look for Cleveland to establish its presence in the paint, create additional scoring opportunities through second-chance possessions, and make enough plays down the stretch to secure the home victory.

Total Pick: Over 229.5

Both teams have the offensive ability to put together big scoring performances, making the over an appealing option in this matchup. Philadelphia has shown it can score in bunches, while Cleveland has enough weapons to consistently put pressure on opposing defenses. The Cavaliers should find success attacking the paint, while Philadelphia will rely on its perimeter scoring to keep pace. Neither team should have much trouble generating quality offensive opportunities if the tempo remains steady. Expect a competitive matchup with plenty of scoring as the game finishes over the total.

Final Picks: Cleveland Cavaliers -2.5 and Over 229.5