St. Louis Cardinals vs Athletics Picks, Prediction, Odds, and Line Movement for Wednesday May 13 2026

By: Kyle Kargel Published 05/13/2026, 09:23 AM ET
Pirates vs Cardinals prediction
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Sutter Health Park has been a launching pad all season long, and Wednesday night's matchup between St. Louis and the Athletics looks tailor-made for another offensive explosion. With game-time temperatures in the low-80s and a breeze pushing straight out to center field, this is one of the most appealing total bets on tonight's MLB slate. For more handicaps on the rest of tonight's action, check out our MLB picks page for full coverage and analysis.

Quick Picks and Prediction

  • Spread Pick: Athletics -1.5
  • Total Pick: Over 10 (EV)
  • Projected Final Score: Athletics 7, Cardinals 5

Odds and Line Movement

Below is a snapshot of the opening odds, current odds, and how the total has moved leading up to first pitch at Sutter Health Park.

Opening Odds

Team Moneyline Total
St. Louis +123 10 (-105)
Athletics -149 10 (-115)

Current Odds

Team Moneyline Total
St. Louis +119 10 (-102)
Athletics -143 10 (-118)

Line Movement - Total

Date Time Over Under Public ($, #)
05/13 05:44:58AM 10 -102 10 -118 OV 100%, OV 100%
05/13 05:39:57AM 9½ -118 9½ -102 OV 100%, OV 100%
05/13 05:38:12AM 10 -102 10 -118 OV 100%, OV 100%
05/13 05:37:57AM 9½ -118 9½ -102 OV 100%, OV 100%
05/13 05:36:56AM 10 -102 10 -118 OV 100%, OV 100%
05/13 05:34:57AM 9½ -118 9½ -102 OV 100%, OV 100%
05/13 05:33:42AM 10 -102 10 -118 OV 100%, OV 100%
05/13 05:32:12AM 9½ -118 9½ -102 OV 100%, OV 100%
05/13 05:14:40AM 10 -102 10 -118 OV 100%, OV 100%
05/13 05:08:56AM 9½ -118 9½ -102 OV 100%, OV 100%
05/13 01:50:52AM 10 -102 10 -118
05/13 12:58:22AM 9½ -118 9½ -102
05/13 12:55:22AM 10 -102 10 -118
05/13 12:54:52AM 9½ -118 9½ -102
05/13 12:54:37AM 10 -102 10 -118
05/13 12:54:22AM 9½ -118 9½ -102
05/13 12:53:22AM 10 -102 10 -118
05/13 12:52:37AM 9½ -118 9½ -102
05/13 12:26:35AM 10 -102 10 -118
05/12 05:40:47PM 10 -105 10 -115

Cardinals vs Athletics Key Matchups and Handicap

The Cardinals and Athletics combined to score ten runs on Tuesday, and we're expecting to see more fireworks tonight. Over bettors had to be pacing in circles after yesterday's game was 4-3 in the bottom of the second inning, but it took several innings before anyone crossed the plate after that. St. Louis eventually earned a 6-4 win, but both teams were forced to use the bullpen pretty aggressively.

Hitting conditions at Sutter Health Park are going to be very favorable this evening with game time temperatures in the low-80s and a mild breeze blowing straight out to center field. We're very interested to see how Athletics starter J.T. Ginn performs on Wednesday after posting one of the best outings of his career against the Phillies last week. Ginn allowed one run on a solo home run in 8.0 innings with eight strikeouts and one walk.

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That was very impressive, but you'll have to excuse our hesitation in backing him on Wednesday because Ginn had never pitched into the seventh inning in his three-year MLB career, let alone complete 8.0 innings. Add in cross-country travel after a road trip in Philadelphia and our fears about his stamina on Wednesday should be justified. Don't forget, Ginn wasn't even a starting pitcher at the start of this season. His first three appearances came out of the bullpen, and he hadn't thrown 6.0 innings (let alone 8.0) prior to last week's win over the Phillies.

On the other side, the Athletics' lineup has done a very nice job producing hard-hit contact this season. The A's enter Wednesday No. 7 in hard-hit rate and No. 6 in expected batting average. Cardinals' starter Matthew Liberatore sits in the bottom-20th percentile among pitchers in expected ERA, expected batting average allowed, average exit velocity, whiff rate and strikeout rate.

  • The total has gone OVER in recent Cardinals games featuring Liberatore on the mound given his struggles with hard contact.
  • The Athletics' lineup ranks No. 7 in hard-hit rate and No. 6 in expected batting average this season.
  • J.T. Ginn is coming off an 8.0-inning, one-run performance against the Phillies, the deepest outing of his three-year MLB career.
  • The Cardinals and Athletics combined for ten runs in Tuesday's series opener, won 6-4 by St. Louis.
  • Public money is hammering the OVER, with 100% of bets and 100% of handle on the OVER in the most recent ticket counts.

STL and ATH Key Injuries and Notes

  • Both bullpens were used aggressively in Tuesday's series opener, which could impact relief options late in this game.
  • J.T. Ginn is making the start for the Athletics after a career-best outing, but is dealing with cross-country travel from Philadelphia.
  • Matthew Liberatore takes the mound for the Cardinals while ranking in the bottom-20th percentile in expected ERA, expected batting average allowed, average exit velocity, whiff rate and strikeout rate.
  • Game-time conditions at Sutter Health Park feature low-80s temperatures and a mild breeze blowing straight out to center field.

Cardinals vs Athletics ATS and Total Picks

  • Spread Pick: Athletics -1.5
  • Total Pick: Over 10 (EV)

The combination of a launching-pad environment, a Cardinals starter who can't miss bats or limit hard contact, and a likely regression from Ginn after a career outing all point to plenty of run-scoring in this one. The Athletics' improved lineup profile and home-field comfort give them the edge on the run line as well.

Final Score Prediction

Athletics 7, Cardinals 5

Expect both lineups to do damage early, with Liberatore's exit-velocity issues showing up against an Athletics lineup that thrives on hard contact. Ginn should be serviceable but is unlikely to replicate last week's masterpiece, especially after cross-country travel and a workload spike. The Athletics bats carry them to a home win in a game that clears the total comfortably.

How to Bet Cardinals vs Athletics

If you're looking to get action down on this Cardinals-Athletics total or the Athletics run line, there are plenty of ways to play. Traditional sportsbooks will obviously have full markets, but if you're in a state without legal sports betting (or just want extra value on a high-total game like this one), social sportsbooks are widely available across the country and offer a great alternative for tonight's slate. Fliff in particular is a strong option for totals like this — claim your bonus with our fliff promo code page and grab some extra coins to put behind the OVER at Sutter Health Park. Whichever route you choose, the betting recommendation stands: Over 10 runs with Athletics -1.5 as the side play.

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