Saint Louis Cardinals at Minnesota Twins Picks and Prediction for Saturday, June 13, 2026
Use Code WWWC St. Louis (33-28) looks to take the road series when they visit Target Field on Saturday afternoon to face Minnesota (29-35) in Game 2 of their three-game set at 2:10 PM ET.  Read on to find out which team picks up the win in this Cardinals vs. Twins prediction. Don’t go down on strikes! Get our top MLB Predictions and increase your bankroll!
Matthew Liberatore, 3-3, 4.35 ERA, will get the start for the Cardinals. The Twins will counter with Connor Prielipp, 1-3, 5.26 ERA.
Cardinals Looking To Take The Series And Keep Surprising
This was supposed to be a rebuilding year for the St. Louis Cardinals. After finishing six games under .500 in 2025, they traded away established veterans like Willson Contreras, Sonny Gray, Nolan Arenado, and Brendan Donovan in the hopes of kick-starting a rebuild around their young roster. Â Instead, a relentlessly on-base offense has the Cardinals at 33-28 and legitimately in the NL Central race.
Liberatore’s most recent start was his best of the season 5.1 scoreless innings against the Cubs on May 31, allowing just three hits and one walk while striking out four in a 5-1 win. Prior to that, he had stumbled through a rough stretch posting a 5.18 ERA, 1.64 WHIP, and 32:10 K:BB across five starts, raising real questions about his consistency. Liberatore has surrendered eight home runs across his starts this season and has been particularly vulnerable to giving up the long ball in bunches, a serious concern at a park that plays at altitude with a compact outfield.
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Twins Trying To Even The Series At Home
The Twins enter Saturday having lost eight of their last 12 games and sitting at 29-35, with their bullpen carrying the second-worst ERA in baseball at 5.83. A win on Saturday would even the series and give Minnesota a chance to take it against a Cardinals club that arrived riding momentum from Friday’s comeback.
The Twins are batting just .279 on the first pitch of at-bats this season, lowest in MLB, and are slugging just .348 against left-handed pitching, the fourth-lowest mark in the league. Byron Buxton leads the offense with 16 home runs and Brooks Lee contributes 30 RBI from the middle of the order, while Tristan Gray has collected 11 hits and 12 RBI across his last 13 games as a productive lower-order contributor.
Prielipp was electric in his first five major league starts, posting a 2.88 ERA with a .169 batting average against and a 0.96 WHIP, generating elite swing-and-miss rates with his hard slider. Over his last three outings, however, the league has caught up to the 25-year-old lefty, he has allowed 15 earned runs across 14.1 innings with a 13:8 K:BB ratio during that stretch, and his season ERA has climbed to 5.26. Prielipp’s pitch-count limitations add another layer of concern, as the Twins are aware he has thrown just roughly 150 career innings since high school, meaning St. Louis will likely get a look at Minnesota’s shaky bullpen by the fifth or sixth inning.
Cardinals vs. Twins Picks
Money Line Pick for Cardinals vs. Twins
- St. Louis Cardinals ML (4 Units)
The Cardinals get the edge here because both starters have significant vulnerability, but St. Louis’s offense is better equipped to capitalize against a pitcher in the kind of form Prielipp has shown over his last three starts. Prielipp’s ERA has ballooned to 5.26 after allowing 15 earned runs in his last 14.1 innings , and a Cardinals lineup that gets on base at an elite rate across the top four spots is precisely the type of patient, disciplined offense that exposes a pitcher whose command has started to crack. Prielipp’s workload limits mean he is unlikely to pitch deep into the game , and once Minnesota turns to a bullpen that ranks 29th in baseball in ERA, the Cardinals’ on-base machine will generate sustained pressure. Liberatore is coming off his best start of the season — five-plus scoreless innings against the Cubs , and with the momentum of Friday’s comeback win, St. Louis has every reason for confidence. Take the Cardinals on the money line.
Over/Under Pick for Cardinals vs. Twins
- Over (4 Units)
Liberatore has surrendered eight home runs across his starts this season and was knocked around badly during a five-start stretch that produced a 5.18 ERA , and Target Field’s elevation and compact outfield set up the kind of fly-ball damage that has hurt him most in 2026. Target Field plays at 840 feet above sea level — the sixth-highest elevation in baseball — with the wind projected to blow out to left field , favoring left-handed power hitters like Buxton at the top of the Twins’ lineup. Prielipp has allowed 15 runs in his last three starts and seen his command erode significantly , opening the door for St. Louis’s patient, high-OBP lineup to work long at-bats and score in bunches once he falls behind in counts. With two left-handed starters both prone to giving up runs and a park that plays hitter-friendly, take the Over.
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