Pittsburgh Pirates vs. Milwaukee Brewers Picks and Prediction for Sunday April 26 2026

By: Ben Hayes Published 04/26/2026, 04:35 AM ET
Pirates vs. Brewers pick and prediction
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Pittsburgh (15-11) hopes to continue its winning ways when they meet Milwaukee (13-12) on Sunday at 2:10 PM ET from American Family Field in Wisconsin. The Pirates won the opener 6-0 on Friday and *played the second game on Saturday night. Before that win by the Pirates, the Brewers had won eight straight games in this series. Check out more baseball free picks and predictions from Winners and Whiners.

*published before Saturday night's results.

Skenes dominates Brewers

Paul Skenes opened the season with an awful appearance for him, allowing 5 runs in 2/3 of an inning against the NY Mets, but got very little help from his defense. He rebounded with five solid starts, allowing just three earned runs and 10 hits in 28.1 innings. On Friday, he was dominant, allowing just one hit, while striking out seven in seven innings to lower his ERA to 2.48. The offense helped out as OF/1B Ryan O'Hearn knocked in two runs and SS Konor Griffin hit his first homer of the season. Pittsburgh is in third place in the NL West, two games behind the Cubs and Reds.

The Pirates will send right-handed Carmen Mlodzinski to the mound. He's 1-1 with a 3.28 ERA, allowing 25 hits and 10 walks in 24.2 innings (1.42 WHIP). In his last start on April 10, he allowed six hits and no runs in 5.1 innings with three walks as the Pirates beat the Cubs 2-0. He's thrown 85 or fewer pitches in his last three starts. Last season, he went 5-8 with a 3.55 ERA in 12 starts and 34 games pitched.

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Brewers are slumping

Milwaukee has now lost three straight games (before Saturday's results), which included dropping two of three at Detroit. On Friday, they sent out Brandon Woodruff against Skenes, and he needed to be incredible to get the win. He wasn't but pitched decently, allowing three runs and five hits in five innings. The Brewers' lineup was silent as they accumulated just one hit against Skenes and the Pirates' bullpen.

Milwaukee will send southpaw Kyle Harrison to the mound, who is 1-1 with a 3.06 ERA with 18 strikeouts in 17.2 innings. He's allowed two homers and walked seven in four starts. Last season, he went 1-1 with a 4.04 ERA in six starts and 11 games. He allowed just four homers in 35.2 innings, walking 14. He faced the Pirates in April of 2024, allowing five hits and no runs in six innings in a 3-0 win while he was with San Francisco.

Spread Pick and Prediction for Pirates vs. Brewers

Pirates vs. Brewers Pick and Odds

  • Milwaukee -124 (4 units)

Harrison is the real deal and the Brewers will need him to be ace-like to win this matchup on Sunday. He's allowed just six runs in four starts this season. He has a 2.89 ERA this season at home. Last season, he recorded a 2.57 ERA during the day. Last season, Mlodinski struggled in April, going 1-2 with a 6.04 ERA. He also struggled on the road, going 1-5 with a 4.38 ERA.

Over/Under Pick for Pirates vs. Brewers

  • Under 7.5 (4 units)

Harrison should have another quality performance against a Pittsburgh team that has gone under in three of their last four games. Milwaukee has scored just six runs in its last three games before Saturday. In head-to-head action, these teams have gone under in three of their last four games.

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