Minnesota Twins vs Philadelphia Phillies Prediction and Picks - Saturday, September 27, 2025

The Minnesota Twins face the Philadelphia Phillies with both teams heading in opposite directions to close out the season. The Twins are 69-91 and will end the season with the second-worst record in the American League Central Division while the Phillies are 94-65 and hope a strong weekend helps them secure the best record in baseball. Who will win this game? Check out our Twins vs Phillies prediction!

When it comes to MLB picks, our MLB Predictions are stellar.

Minnesota hopes Ryan helps out awful lineup

The Twins are wrapping up a season to forget and hope to end things on a high note. Joe Ryan is one of the bright spots as he’s allowed only 67 runs in 166 innings pitched while tossing 185 strikeouts. Moreover, with a .221 expected opponent Batting Average, a 5.7 Walk Rate, and a 3.57 expected ERA, opponents are making minimal contact and struggling to drive in runs against Ryan this season.

Ryan has stepped up but the lineup has let the Twins down this season, scoring only 4.22 runs per game. Byron Buxton is slashing .263/.327/.539 with 32 home runs and 256 total bases while Luke Keaschall is slashing .302/.382/.445 with 81 total bases but the rest of the lineup has struggled. Only four active batters have an OPS+ over 100 and opposing pitchers can limit the top-heavy lineup as a result.

Phillies hope lineup helps out Nola

The Phillies are having a remarkable season and hope to secure the best record in baseball. Aaron Nola will start the upcoming game, and he looks to improve on what’s been a rough season on the mound as he’s allowed 64 runs in 86 innings pitched. Additionally, with a .267 expected opponent Batting Average, a .457 expected opponent Slugging Percentage, and a 4.64 expected ERA, opponents are making hard contact and driving in runs at will against Nola this season.

Nola has struggled, but the lineup is one of the best in baseball, scoring 4.89 runs per game. Kyle Schwarber is slashing .246/.370/.576 with 56 home runs and 340 total bases, while Bryce Harper is slashing .263/.358/.495 with 27 home runs and 241 total bases, but the rest of the lineup has stepped up as well. Trea Turner is slashing .305/.356/.458 with 15 home runs and 269 total bases, while Brandon Marsh and Alec Bohm have added 22 home runs and 348 total bases to round out the lineup, making the Phillies tough to put away at the plate.

Twins vs Phillies Prediction

Spread Pick for Twins vs. Phillies

• Phillies .1.5 (-110) (4 Units)

The Phillies are having a great season, and they look to dominate this game from the first inning. The Phillies should drive in runs at will with Kyle Schwarber, Brandon Marsh, and the rest of the batting order making contact and putting together strong plate appearances. The Phillies should limit the Twins' lineup, which averages only 4.22 runs per game, with Aaron Nole stepping up and pitching multiple scoreless innings to allow the bullpen to close out the game with a lead. The Phillies should win the game and cover the spread with a strong performance at home.

Over/Under Pick for Twins vs. Phillies

• Over 8.5 (5 Units)

The Phillies have a great lineup, and this game looks to be a high-scoring one from the first inning. The Twins should constantly plate baserunners with Byron Buxton, Luke Keaschall, and the rest of the lineup making contact and putting together strong plate appearances. The Phillies, who average 4.89 runs per game, should run up the score with Kyle Schwarber, Bryce Harper, Trea Turner, and the rest of the batting order swinging for the fences and crushing pitches to drive in runs at will. The Over should cover in a high-scoring game with both lineups stepping up.

Take the Over on 8.5 runs.