Minnesota Twins vs. Cleveland Guardians Picks and Prediction for Sunday, May 10, 2026
Use Code WWWC It’s the conclusion of a series on the diamond between a pair of American League Central teams hoping to build some positive momentum on the shores of Lake Erie as the Minnesota Twins play the final game of a three-game set with the Cleveland Guardians Sunday afternoon and we have you covered with our Twins vs. Guardians prediction. Cleveland drew first blood in the set by prevailing 6o4 in the series opener Friday night. Will the Twins leave town with momentum or can Cleveland secure the win in the series finale? This article was published prior to the conclusion of the second game of the series at Progressive Field Saturday night. Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks! Read more about this Twins vs. Guardians prediction!
Twins Seeking to Get Back on Track
Minnesota dropped their third straight and fifth in the last seven games as they fell in the opener of this set. The Twins entered Saturday 16-23 and sat in the basement of the AL Central, 4.5 games behind Cleveland for the top spot. Against Cleveland Friday night, Minnesota had 13 hits with Byron Buxton (two runs, two RBI) and Austin Martin (run) each picking up three. Buxton (his 12th) went deep but the team was three of 12 with runners in scoring position in the loss. Connor Prielipp (1-1) took the loss as he allowed four runs (one earned) on four hits with two walks and six strikeouts over five innings of work.
Taj Bradley is on the mound as he makes his ninth start of the season for the Twins in this contest. He is 4-1 with a 2.87 ERA, a 1.191 WHIP, 17 walks and 52 strikeouts over 47 innings of work this year. Bradley earned the win in his last start, which came against the Nationals Tuesday night on the road. He threw six innings, allowing two runs on four hits with two walks and eight strikeouts in an 11-3 Twins win. In his last three starts, Bradley is 1-0 with a 4.66 ERA, a 1.14 WHIP, seven walks and 18 strikeouts over 19.1 innings of work. Bradley makes his fourth career start against the Guardians in this contest. He is 1-1 with a 1.65 ERA, a 1.408 WHIP, 10 walks and 21 strikeouts over 16.1 innings of work against them. Bradley is 0-1 with a 2.89 ERA, a 1.714 WHIP, eight walks and 13 strikeouts over 9.1 innings in two career starts at Progressive Field.
Cleveland Looking to Build AL Central Edge
Cleveland won their third straight as they jumped in front early Friday night en route to the victory. The Guardians entered Saturday 21-19 and owned a 2.5-game advantage on the Tigers and Royals for the top spot in the AL Central. On Friday night, Cleveland finished with eight hits as Steven Kwan (two runs) and Jose Ramirez (run, RBI) each had two. Travis Bazzana (his first) went deep in the win for the Guardians. Parker Messick (4-1) earned the win as he allowed one run on seven hits with one walk and seven strikeouts over 5.2 innings of work. Cade Smith worked the ninth, allowing one run on two hits with no walks and one strikeout, for his 11th save.
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Gavin Williams takes the bump for his ninth start of the year for the Guardians here on getaway day. He is 5-2 with a 3.28 ERA, a 1.095 WHIP, 21 walks and 60 strikeouts over 49.1 innings of work on the year. Williams took the loss in his last start, which came against the Royals on the road Tuesday. He tossed six innings, allowing five runs on eight hits with two walks and seven strikeouts in a 5-3 Guardians loss. In his last three starts, Williams is 2-1 with a 5.03 ERA, a 1.22 WHiP, four walks and 20 strikeouts over 19.2 innings of work. Williams makes his eighth career start against the Twins. He is 3-2 with a 2.61 ERA, a 1.161 WHIP, 13 walks and 30 strikeouts over 31 innings of work. Williams is 12-12 with a 3.58 ERA, a 1.262 WHIP, 80 walks and 227 strikeouts over 193.1 innings in 36 career starts at Progressive Field.
Twins vs. Guardians Pick
Moneyline Pick for Twins vs. Guardians
- Guardians (4 units)
Minnesota is trending in the wrong direction with five losses in their last seven games entering Saturday. The Twins do have their most reliable arm in the early going on the bump here in Bradley but that doesn’t mean much when the team is struggling. Cleveland is atop the AL Central, though it’s a mediocre division at the moment. The Guardians are at home, where they are 10-7 this season, while the Twins are just 6-13 on the road. Give the upper hand to Cleveland as they ride their recent momentum to a series victory by prevailing in the finale.
Over/Under Pick for Twins vs. Guardians
- Under (4 units)
Minnesota entered Saturday with the over posting a 25-13-1 mark in their opening 39 games of the year. The Twins are tied for 8th by averaging 4.79 runs per game, a number that slips down to 4.58 runs per game on the road. Minnesota has an average total of 9.95 runs per game on the season and that bumps slightly to 10.21 runs per game away from Target Field. Cleveland entered Saturday night having stayed under the total in 20 of their 40 games on the season. The Guardians are 21st in the majors with 4.20 runs per game, a number that falls to 3.82 runs per game at home. Cleveland has an average total of 8.45 runs per game and that number drops to 6.94 runs per game at home this season. With two good pitchers, take the under here.
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