Oregon vs Ohio State Picks and Predictions for Saturday, November 7, 2026

Oregon travels to Columbus on Saturday to face No. 11 Ohio State at Ohio Stadium. Kickoff is scheduled for 3:30 pm ET on CBS. The Ducks (5-3, 3-2 Big Ten, tied for 5th) beat Northwestern 34-26 last Saturday, while the Buckeyes (6-2, 4-1 Big Ten, 3rd) lost 30-18 to USC. Oregon has split its last four games, and Ohio State is trying to recover from its second defeat of the season. Find more Saturday matchups in our free college football picks.

Oregon Trying to Find Some Consistency

Oregon finally got its offense moving against Northwestern, putting up 34 points after scoring just 10 in a loss to Illinois. The Ducks needed that response. They've been up and down throughout October, with close games against Nebraska and UCLA showing how little separates their better performances from their frustrating ones. Oregon has the talent to challenge Ohio State, but another slow start could make things difficult in Columbus.

Dylan Raiola has thrown for 1,097 yards, nine touchdowns and two interceptions, completing 66.2% of his passes. Jordon Davison leads Oregon with 439 rushing yards and seven touchdowns. Dakorien Moore has supplied the biggest receiving numbers, catching 41 passes for 545 yards and six scores. Defensively, Matayo Uiagalelei has six sacks, while Koi Perich leads with 53 tackles.

Injuries: Iverson Hooks, Aaron Flowers and Jeremiah McClellan are out. Evan Stewart, Dorian Gresham and Sione Price are questionable.

Ohio State Dealing With a Major Quarterback Absence

USC handed Ohio State a 30-18 defeat last Saturday, snapping the Buckeyes' four-game winning streak. It wasn't the performance Ohio State wanted after beating Indiana 19-15 in its previous outing. The Buckeyes have generally scored well this season, but the loss in Los Angeles exposed a problem they'll need to solve quickly. Oregon arrives with a capable pass rush, making Ohio State's situation at quarterback particularly important.

Julian Sayin has thrown for 2,007 yards and 19 touchdowns, but he's listed as out with an arm injury. That leaves Luke Fahey, who has 463 passing yards, three touchdowns and two interceptions, among the alternatives. Jeremiah Smith has been Ohio State's main receiving threat, collecting 1,067 yards and 13 touchdowns. Bo Jackson leads the rushing attack with 637 yards, although he's questionable with a shoulder injury. Losing both offensive starters would put considerable pressure on the Buckeyes.

Injuries: Julian Sayin and Ja'Kobi Jackson are out. Bo Jackson, Aaron Valerio-Hudson, Turbo Rogers and Bennett Christian are questionable.

Key To The Game

Ohio State's quarterback change is the matchup to watch. Sayin's absence removes the Buckeyes' leading passer, and Jackson's uncertain availability adds another concern. Oregon has six sacks from Uiagalelei and will look to pressure whoever starts. The Ducks still need to produce more consistently on offense to take advantage.

Oregon vs Ohio State Game Pick

• Oregon Ducks +7

Seven points is a useful cushion for Oregon, especially with Ohio State missing Sayin. The Buckeyes have been dangerous through the air, but replacing a quarterback with 19 touchdown passes changes the matchup. Jackson's shoulder injury also creates uncertainty in the backfield. Oregon hasn't been steady offensively, so there's a risk the Ducks fall behind early. Still, their defense has enough pass-rushing ability to trouble a less experienced quarterback, and last week's win over Northwestern should help their confidence. I expect Ohio State to compete at home, but Oregon can stay within a touchdown. Take the Ducks +7.

Oregon vs Ohio State Over/Under Pick

• Under 46.5

Ohio State's quarterback situation points toward a more cautious offensive approach. Sayin is out, Jackson is questionable, and the Buckeyes managed 18 points in their latest loss to USC. Oregon has had its own scoring problems, including 10 points against Illinois and 15 against UCLA. The Ducks did bounce back against Northwestern, but Ohio State presents a different challenge on defense. I can see both teams relying on the running game and taking fewer chances through the air. That should keep this contest closer than the market expects without producing many points. I'll take under 46.5.