Duke Blue Devils vs Notre Dame Fighting Irish Picks, Prediction, Odds, and Line Movement for Tuesday February 24 2026

By: Kyle Kargel Published 02/24/2026, 09:50 AM ET
Duke vs Notre Dame prediction

Duke vs Notre Dame picks bring a classic ACC matchup to Purcell Pavilion, and the number tells you exactly how the market views this one. If you are looking for sharp college basketball picks, this game comes down to whether Notre Dame can score enough to stay within a massive spread.

Quick Picks and Prediction

  • Spread Pick: Duke -17.5
  • Total Pick: Under 140.5
  • Projected Final Score: Duke 78, Notre Dame 58

Odds and Line Movement

Opening Odds

Market Duke Notre Dame
Spread -17.5 (-110) +17.5 (-110)
Total Over 138.5 (-115) Under 138.5 (-105)

Current Odds

Market Duke Notre Dame
Spread -18.5 (-120) +18.5 (-102)
Total Over 140.5 (-106) Under 140.5 (-114)

Line Movement - Spread

Date Time Duke Notre Dame Public ($, #)
02/24 09:13:00AM -17.5 -110 17.5 -110 DUKE 98%, DUKE 80%
02/24 08:31:29AM -18.5 -102 18.5 -120 DUKE 99%, DUKE 87%
02/23 05:09:18PM -18.5 -102 18.5 -120 DUKE 100%, DUKE 100%
02/23 02:33:20PM -17.5 -110 17.5 -110

Line Movement - Total

Date Time Over Under Public ($, #)
02/24 08:31:29AM 140.5 -106 140.5 -114 OV 75%, OV 50%
02/24 12:14:15AM 140.5 -106 140.5 -114 OV 100%, OV 100%
02/23 05:19:34PM 139.5 -115 139.5 -105
02/23 02:33:20PM 138.5 -115 138.5 -105

Duke

The Blue Devils enter at 25-2, pairing an 82.4 points-per-game offense with a defense that allows just 63.1 points per contest. That balance travels well, especially in conference play.

Duke can attack inside with size and rim pressure while also rotating defenders in waves. Depth has not been a major issue outside of minor rotation absences.

Notre Dame

The Irish have struggled at 12-15, and injuries have reshaped the rotation. Markus Burton, the team’s top creator and scorer at 18.5 points per game in limited action, remains out with an ankle injury.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Without Burton’s downhill ability, Notre Dame leans on Braeden Shrewsberry and Cole Certa. When the offense stalls into contested mid-range attempts, efficiency drops quickly.

Duke vs Notre Dame

Duke’s defense forces tough shots and rarely gives away easy points. Against a thin Notre Dame frontcourt, the Blue Devils should control the glass and limit second-chance opportunities.

If Duke reaches the mid-to-high 70s, the burden falls on Notre Dame to keep pace. That is a tall order given current roster limitations and Duke’s defensive baseline.

Duke vs Notre Dame Key Matchups and Handicap

The spread has climbed from -17.5 to -18.5 with overwhelming public support on Duke. Even with the inflated number, the matchup edge remains clear.

Notre Dame’s missing frontcourt depth makes rebounding a concern. Duke’s ability to attack the paint and defend without fouling should keep this game at a controlled tempo.

The total has ticked up from 138.5 to 140.5, but the under still holds value. If Duke controls pace and limits efficient looks, Notre Dame may struggle to reach 60 points.

  • Duke is 25-2 entering this matchup.
  • Notre Dame is 12-15 on the season.
  • The spread moved from -17.5 to -18.5.
  • The total moved from 138.5 to 140.5.
  • Public money heavily backs Duke.

Key Injuries and Notes - DUKE and ND

  • Markus Burton is out for Notre Dame with an ankle injury.
  • Jalen Haralson is out.
  • Kebba Njie and Tommy Ahneman are out with knee injuries.
  • Duke’s only notable absence is depth piece Ifeanyi Ufochukwu.

ATS and Total Picks

  • ATS Pick: Duke -17.5
  • Total Pick: Under 140.5

Final Score Prediction

Duke 78, Notre Dame 58

How to Bet

With heavy public support pushing the spread higher, timing your wager is important. Compare prices across the best sportsbooks before placing your bet.

Take advantage of available sportsbook promo codes and explore social sportsbooks for alternative wagering options. You can also look into offers like the bet365 bonus code and the fliff promo code to maximize value before tip-off.

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.